MATTOCCIA LABS / RESEARCH ENGINES / ENGINE 02

Genomics Evidence Engine.
Experiment GEE-001.

Classificatory discordance in public BRCA1/BRCA2 variant evidence.

Study context

Problem addressed: Where do aggregate ClinVar conflicts and differences across organizations diverge?
Contribution relative to existing methods: The experiment records the two counts separately under explicit same-condition and provenance rules.
Potential commercial use: Use the report as a template for triaging reviews of public evidence in a research workflow.

Market context and value assumptions on the engine page

GEE-001

Experiment conclusions

ClinVar reported 12 aggregate conflicts in the sample of 80 BRCA1 and BRCA2 variants. Of the 75 variants comparable for the same condition, 28 had different classifications across submitting organizations. Separating these measures shows where disagreements arise.

Study limits. The fixed selection rule does not produce a representative sample of the whole archive. The study documents the published classifications without making clinical reassessments.

Experimental research only. Not a diagnostic system, medical advice or a clinical reassessment. Public variant-level data attributed to NCBI ClinVar and Ensembl; original software Apache-2.0. No personal genetic data, patient observations or AI-generated numeric results.

Acquired: 2026-11-06T00:53:36.456082+00:00 · method gee-001-1.0 · analysis SHA256 7a8667032c123a7bd4841d34769d179e3a2f8dd7c7d876a5c180dc6c38b9e1b0

80Unique variants

543Condition records / RCV

1770Germline submissions / SCV

164Unique submitter IDs

Selection and denominators

{
  "genes": [
    "BRCA1",
    "BRCA2"
  ],
  "rule": "First N unique numeric ascending Variation IDs per official gene AND single_gene query; selected before classifications are fetched",
  "per_gene_requested": 40,
  "searches": {
    "BRCA1": {
      "query": "BRCA1[gene] AND single_gene[prop]",
      "available_ids": 14132,
      "selected_ids": [
        17660,
        17661,
        17662,
        17665,
        17666,
        17667,
        17669,
        17670,
        17675,
        17676,
        17677,
        17679,
        17681,
        17682,
        17683,
        17685,
        17690,
        17693,
        17694,
        17695,
        37386,
        37387,
        37388,
        37389,
        37390,
        37391,
        37392,
        37393,
        37394,
        37395,
        37396,
        37397,
        37398,
        37399,
        37400,
        37401,
        37402,
        37403,
        37404,
        37405
      ],
      "not_selected": 14092,
      "source_id": "e70b327ae158dae56a039992e05d2c7c0df5f727508b90d25632414613856a67"
    },
    "BRCA2": {
      "query": "BRCA2[gene] AND single_gene[prop]",
      "available_ids": 22046,
      "selected_ids": [
        9317,
        9318,
        9319,
        9320,
        9322,
        9324,
        9325,
        9326,
        9328,
        9329,
        9339,
        9340,
        9342,
        9343,
        9344,
        9345,
        9346,
        9347,
        9348,
        9349,
        37714,
        37715,
        37716,
        37717,
        37718,
        37719,
        37720,
        37721,
        37722,
        37723,
        37724,
        37725,
        37726,
        37727,
        37728,
        37729,
        37730,
        37731,
        37732,
        37733
      ],
      "not_selected": 22006,
      "source_id": "ad55e9d803cb35c6f1a71e27977e81fa9f790f55acd59e5c92a801c4ecf8744d"
    }
  },
  "selected_unique_ids": [
    9317,
    9318,
    9319,
    9320,
    9322,
    9324,
    9325,
    9326,
    9328,
    9329,
    9339,
    9340,
    9342,
    9343,
    9344,
    9345,
    9346,
    9347,
    9348,
    9349,
    17660,
    17661,
    17662,
    17665,
    17666,
    17667,
    17669,
    17670,
    17675,
    17676,
    17677,
    17679,
    17681,
    17682,
    17683,
    17685,
    17690,
    17693,
    17694,
    17695,
    37386,
    37387,
    37388,
    37389,
    37390,
    37391,
    37392,
    37393,
    37394,
    37395,
    37396,
    37397,
    37398,
    37399,
    37400,
    37401,
    37402,
    37403,
    37404,
    37405,
    37714,
    37715,
    37716,
    37717,
    37718,
    37719,
    37720,
    37721,
    37722,
    37723,
    37724,
    37725,
    37726,
    37727,
    37728,
    37729,
    37730,
    37731,
    37732,
    37733
  ],
  "sample_type": "deterministic_nonrandom_not_prevalence_estimate",
  "ensembl_selection_rule": "Round-robin by gene, ascending selected Variation ID among exact GRCh38 SNVs; fixed limit before VEP responses",
  "ensembl_selected_ids": [
    "17660",
    "9329",
    "17661",
    "9339",
    "17670",
    "9340",
    "17675",
    "9343",
    "17676",
    "9344",
    "17681",
    "9345"
  ]
}

This is a deterministic lowest-ID sample, not a random sample or estimate of all BRCA variants. RCVs and SCVs are not counted as variants. Scope excludes nonclassified/haplotype/nonhuman/other-gene records with reasons retained below.

1 / Quantitative results

Official aggregate germline conflict: 12 / 80 (15.0%). Same-condition cross-band SCV difference: 28 / 75 (37.333%) of variants with at least one comparable condition group.

Official source label	Count
Benign	8
Benign/Likely benign	3
Conflicting classifications of pathogenicity	12
Likely benign	2
Pathogenic	50
Pathogenic/Likely pathogenic	4
Uncertain significance	1

2 / Documented examples

OBSERVED DATA / COMPUTATIONAL COMPARISON

VCV000037388.28

NM_007294.4(BRCA1):c.1033G>T (p.Asp345Tyr)

Official VCV aggregate: Conflicting classifications of pathogenicity · criteria provided, conflicting classifications

MedGen:C0027672 · ['B/LB', 'VUS'] · 3 SCVs; 3 submitters.

RCVs: RCV000509756.15

SCV	Submitter	Classification	Review	Evaluation	Contributes
SCV000607932.6	Ambry Genetics	Uncertain significance	criteria provided, single submitter	2025-05-01	True
SCV000688313.4	Color Diagnostics, LLC DBA Color Health	Uncertain significance	criteria provided, single submitter	2020-09-30	True
SCV003846214.1	University of Washington Department of Laboratory Medicine, University of Washington	Likely benign	criteria provided, single submitter	2023-03-23	True

OBSERVED DATA / COMPUTATIONAL COMPARISON

VCV000037398.31

NM_007294.4(BRCA1):c.1202G>A (p.Gly401Glu)

Official VCV aggregate: Conflicting classifications of pathogenicity · criteria provided, conflicting classifications

MedGen:C0027672 · ['B/LB', 'VUS'] · 3 SCVs; 3 submitters.

RCVs: RCV000130767.18

SCV	Submitter	Classification	Review	Evaluation	Contributes
SCV000185660.9	Ambry Genetics	Likely benign	criteria provided, single submitter	2024-04-15	True
SCV000688321.5	Color Diagnostics, LLC DBA Color Health	Uncertain significance	criteria provided, single submitter	2025-05-13	True
SCV003846107.1	University of Washington Department of Laboratory Medicine, University of Washington	Likely benign	criteria provided, single submitter	2023-03-23	True

OBSERVED DATA / COMPUTATIONAL COMPARISON

VCV000037399.26

NM_007294.4(BRCA1):c.1222A>G (p.Lys408Glu)

Official VCV aggregate: Conflicting classifications of pathogenicity · criteria provided, conflicting classifications

MedGen:C2676676 · ['B/LB', 'VUS'] · 3 SCVs; 3 submitters.

RCVs: RCV000030980.11

SCV	Submitter	Classification	Review	Evaluation	Contributes
SCV000053572.3	Sharing Clinical Reports Project (SCRP)	Benign	no assertion criteria provided	2009-11-06	False
SCV000144033.1	Breast Cancer Information Core (BIC) (BRCA1)	Uncertain significance	no assertion criteria provided	2002-06-20	False
SCV004244133.1	BRCAlab, Lund University	Uncertain significance	no assertion criteria provided	2020-03-02	False

OBSERVED DATA / COMPUTATIONAL COMPARISON

VCV000037402.33

NM_007294.4(BRCA1):c.134A>C (p.Lys45Thr)

Official VCV aggregate: Conflicting classifications of pathogenicity · criteria provided, conflicting classifications

MedGen:C2676676 · ['B/LB', 'VUS'] · 4 SCVs; 4 submitters.

RCVs: RCV000030983.21

SCV	Submitter	Classification	Review	Evaluation	Contributes
SCV000053575.4	Sharing Clinical Reports Project (SCRP)	Uncertain significance	no assertion criteria provided	2010-05-03	False
SCV000144426.1	Breast Cancer Information Core (BIC) (BRCA1)	Uncertain significance	no assertion criteria provided	2004-02-20	False
SCV000488132.3	Counsyl	Uncertain significance	no assertion criteria provided	2016-02-19	False
SCV004823696.1	All of Us Research Program, National Institutes of Health	Likely Benign	criteria provided, single submitter	2023-09-04	True

OBSERVED DATA / COMPUTATIONAL COMPARISON

VCV000037405.20

NM_007294.4(BRCA1):c.135-8dup

Official VCV aggregate: Conflicting classifications of pathogenicity · criteria provided, conflicting classifications

MedGen:C0027672 · ['B/LB', 'VUS'] · 2 SCVs; 2 submitters.

RCVs: RCV001176119.15

MedGen:C2676676 · ['B/LB', 'VUS'] · 3 SCVs; 3 submitters.

RCVs: RCV000030986.15

SCV	Submitter	Classification	Review	Evaluation	Contributes
SCV000053578.3	Sharing Clinical Reports Project (SCRP)	Uncertain significance	no assertion criteria provided	2011-06-01	False
SCV001339967.4	Color Diagnostics, LLC DBA Color Health	Likely benign	criteria provided, single submitter	2023-09-04	True
SCV002538016.1	Sema4, Sema4	Uncertain significance	criteria provided, single submitter	2021-05-19	True
SCV004244191.1	BRCAlab, Lund University	Uncertain significance	no assertion criteria provided	2020-03-02	False
SCV004828697.1	All of Us Research Program, National Institutes of Health	Likely Benign	criteria provided, single submitter	2023-09-17	True

OBSERVED DATA / COMPUTATIONAL COMPARISON

VCV000037715.26

NM_000059.4(BRCA2):c.-39-12_-39-10del

Official VCV aggregate: Conflicting classifications of pathogenicity · criteria provided, conflicting classifications

MedGen:C2675520 · ['B/LB', 'VUS'] · 3 SCVs; 3 submitters.

RCVs: RCV000031296.9

SCV	Submitter	Classification	Review	Evaluation	Contributes
SCV000053901.4	Sharing Clinical Reports Project (SCRP)	Benign	no assertion criteria provided	2010-12-17	False
SCV000145913.1	Breast Cancer Information Core (BIC) (BRCA2)	Uncertain significance	no assertion criteria provided	2002-05-29	False
SCV002761800.1	Genetics and Molecular Pathology, SA Pathology	Uncertain significance	criteria provided, single submitter	2020-04-27	True

OBSERVED DATA / COMPUTATIONAL COMPARISON

VCV000037717.29

NM_000059.4(BRCA2):c.-9T>C

Official VCV aggregate: Conflicting classifications of pathogenicity · criteria provided, conflicting classifications

MedGen:C2675520 · ['B/LB', 'VUS'] · 3 SCVs; 3 submitters.

RCVs: RCV000031298.9

SCV	Submitter	Classification	Review	Evaluation	Contributes
SCV000053903.3	Sharing Clinical Reports Project (SCRP)	Likely benign	no assertion criteria provided	2011-12-01	False
SCV000145989.1	Breast Cancer Information Core (BIC) (BRCA2)	Uncertain significance	no assertion criteria provided	2002-05-29	False
SCV000785751.3	Counsyl	Uncertain significance	no assertion criteria provided	2017-11-20	False

OBSERVED DATA / COMPUTATIONAL COMPARISON

VCV000037718.27

NM_000059.4(BRCA2):c.10024G>A (p.Glu3342Lys)

Official VCV aggregate: Conflicting classifications of pathogenicity · criteria provided, conflicting classifications

MedGen:C0027672 · ['B/LB', 'VUS'] · 2 SCVs; 2 submitters.

RCVs: RCV000220854.11

SCV	Submitter	Classification	Review	Evaluation	Contributes
SCV000274258.7	Ambry Genetics	Uncertain significance	criteria provided, single submitter	2025-06-10	True
SCV000911853.1	Color Diagnostics, LLC DBA Color Health	Likely benign	criteria provided, single submitter	2018-01-03	True

3 / Documentary completeness

Official source label	Count
criteria provided, conflicting classifications	12
criteria provided, multiple submitters, no conflicts	11
criteria provided, single submitter	3
no assertion criteria provided	2
reviewed by expert panel	52

SCVs with declared criteria: 1287 / 1770 (72.712%); evaluation date: 1606 / 1770 (90.734%); citation identifiers: 1112 / 1770 (62.825%). These are metadata availability indicators, not scientific reliability scores.

Expert-panel VCVs: 52 / 80 (65.0%). Submitter organization categories below are SCV-weighted, denominator 1770 submissions, not unique organizations.

Official source label	Count
clinic	75
consortium	228
laboratory	1338
locus-specific database (LSDB)	58
other	11
patient registry	7
resource	53

Distinct submitter organizations

Organization IDs deduplicated across the study; denominator 164 organizations. A combined label is retained if source categories differ.

Official source label	Count
clinic	11
consortium	10
laboratory	133
locus-specific database (LSDB)	2
other	5
patient registry	1
resource	2

Cross-source annotation

Exact GRCh38 SNV match to Ensembl VEP: 12 / 12 (100.0%) attempted compatible variants. Predicted molecular consequence is independent of the clinical classification.

{
  "server_release": {
    "releases": [
      116
    ]
  },
  "attempted": 12,
  "matched_variants": [
    {
      "vcv": "VCV000009329.101",
      "variation_id": "9329",
      "location": {
        "assembly": "GRCh38",
        "sequence_accession": "NC_000013.11",
        "chromosome": "13",
        "position": 32332592,
        "start": 32332592,
        "stop": 32332592,
        "reference": "A",
        "alternate": "C",
        "representation": "VCF 1-based forward genomic"
      },
      "consequence": "missense_variant",
      "verified_gene_ids": [
        "ENSG00000139618"
      ],
      "transcript_count": 15,
      "source_id": "2dc0ee6448b630f57f54f576641e84ffc2ca95a6a8fc06e163fe871a374545f1"
    },
    {
      "vcv": "VCV000009339.8",
      "variation_id": "9339",
      "location": {
        "assembly": "GRCh38",
        "sequence_accession": "NC_000013.11",
        "chromosome": "13",
        "position": 32376769,
        "start": 32376769,
        "stop": 32376769,
        "reference": "C",
        "alternate": "A",
        "representation": "VCF 1-based forward genomic"
      },
      "consequence": "missense_variant",
      "verified_gene_ids": [
        "ENSG00000139618"
      ],
      "transcript_count": 15,
      "source_id": "692622de3862487af511f812e09360cbe1f409ed2eed7593067da3fbd6e2333f"
    },
    {
      "vcv": "VCV000009340.65",
      "variation_id": "9340",
      "location": {
        "assembly": "GRCh38",
        "sequence_accession": "NC_000013.11",
        "chromosome": "13",
        "position": 32363367,
        "start": 32363367,
        "stop": 32363367,
        "reference": "C",
        "alternate": "G",
        "representation": "VCF 1-based forward genomic"
      },
      "consequence": "missense_variant",
      "verified_gene_ids": [
        "ENSG00000139618"
      ],
      "transcript_count": 14,
      "source_id": "541a61c0e85d9806e079a5719c086daf12abbfd61b6541082032c3ee01c11351"
    },
    {
      "vcv": "VCV000009343.12",
      "variation_id": "9343",
      "location": {
        "assembly": "GRCh38",
        "sequence_accession": "NC_000013.11",
        "chromosome": "13",
        "position": 32363421,
        "start": 32363421,
        "stop": 32363421,
        "reference": "T",
        "alternate": "A",
        "representation": "VCF 1-based forward genomic"
      },
      "consequence": "stop_gained",
      "verified_gene_ids": [
        "ENSG00000139618"
      ],
      "transcript_count": 14,
      "source_id": "020372bea2b1214f88b04cf3ccd6c101ddbf363300b0804e0fefb90ab3eac70f"
    },
    {
      "vcv": "VCV000009344.24",
      "variation_id": "9344",
      "location": {
        "assembly": "GRCh38",
        "sequence_accession": "NC_000013.11",
        "chromosome": "13",
        "position": 32339003,
        "start": 32339003,
        "stop": 32339003,
        "reference": "G",
        "alternate": "T",
        "representation": "VCF 1-based forward genomic"
      },
      "consequence": "stop_gained",
      "verified_gene_ids": [
        "ENSG00000139618"
      ],
      "transcript_count": 14,
      "source_id": "b0cd89b059379f64bac9dbc6d18c8f4a7c12e1253da20431342dc1f600fccb85"
    },
    {
      "vcv": "VCV000009345.25",
      "variation_id": "9345",
      "location": {
        "assembly": "GRCh38",
        "sequence_accession": "NC_000013.11",
        "chromosome": "13",
        "position": 32356521,
        "start": 32356521,
        "stop": 32356521,
        "reference": "T",
        "alternate": "C",
        "representation": "VCF 1-based forward genomic"
      },
      "consequence": "missense_variant",
      "verified_gene_ids": [
        "ENSG00000139618"
      ],
      "transcript_count": 14,
      "source_id": "6ec11a065d8acc07867714d36f25a352d411f5f771e98e7e1d02ca69e8888cf3"
    },
    {
      "vcv": "VCV000017660.43",
      "variation_id": "17660",
      "location": {
        "assembly": "GRCh38",
        "sequence_accession": "NC_000017.11",
        "chromosome": "17",
        "position": 43106478,
        "start": 43106478,
        "stop": 43106478,
        "reference": "A",
        "alternate": "C",
        "representation": "VCF 1-based forward genomic"
      },
      "consequence": "stop_lost",
      "verified_gene_ids": [
        "ENSG00000012048"
      ],
      "transcript_count": 53,
      "source_id": "c760148fbd06c8bc6d0a4511c89b3da4d840fff83295aaa6d044c669b2f6af99"
    },
    {
      "vcv": "VCV000017661.165",
      "variation_id": "17661",
      "location": {
        "assembly": "GRCh38",
        "sequence_accession": "NC_000017.11",
        "chromosome": "17",
        "position": 43106487,
        "start": 43106487,
        "stop": 43106487,
        "reference": "A",
        "alternate": "C",
        "representation": "VCF 1-based forward genomic"
      },
      "consequence": "missense_variant",
      "verified_gene_ids": [
        "ENSG00000012048"
      ],
      "transcript_count": 53,
      "source_id": "52f3c15db232bb29a1eef3729e9254decc2fb31c18053bf80dfc749b9e5c7fba"
    },
    {
      "vcv": "VCV000017670.129",
      "variation_id": "17670",
      "location": {
        "assembly": "GRCh38",
        "sequence_accession": "NC_000017.11",
        "chromosome": "17",
        "position": 43092412,
        "start": 43092412,
        "stop": 43092412,
        "reference": "C",
        "alternate": "T",
        "representation": "VCF 1-based forward genomic"
      },
      "consequence": "missense_variant",
      "verified_gene_ids": [
        "ENSG00000012048"
      ],
      "transcript_count": 50,
      "source_id": "f8e531ed466cc88cf2602825f233cda9ed500b7b510127012558fb9bda59f324"
    },
    {
      "vcv": "VCV000017675.112",
      "variation_id": "17675",
      "location": {
        "assembly": "GRCh38",
        "sequence_accession": "NC_000017.11",
        "chromosome": "17",
        "position": 43082434,
        "start": 43082434,
        "stop": 43082434,
        "reference": "G",
        "alternate": "A",
        "representation": "VCF 1-based forward genomic"
      },
      "consequence": "stop_gained",
      "verified_gene_ids": [
        "ENSG00000012048"
      ],
      "transcript_count": 48,
      "source_id": "51d93c76560c92830118ed3cbdec9c33af96090bb442f1e9792439e0ef96e71b"
    },
    {
      "vcv": "VCV000017676.78",
      "variation_id": "17676",
      "location": {
        "assembly": "GRCh38",
        "sequence_accession": "NC_000017.11",
        "chromosome": "17",
        "position": 43082434,
        "start": 43082434,
        "stop": 43082434,
        "reference": "G",
        "alternate": "C",
        "representation": "VCF 1-based forward genomic"
      },
      "consequence": "missense_variant",
      "verified_gene_ids": [
        "ENSG00000012048"
      ],
      "transcript_count": 48,
      "source_id": "851aab031256dfb28e254748904d4ec6c40f58823fee62fa818d942f3f85071a"
    },
    {
      "vcv": "VCV000017681.112",
      "variation_id": "17681",
      "location": {
        "assembly": "GRCh38",
        "sequence_accession": "NC_000017.11",
        "chromosome": "17",
        "position": 43093010,
        "start": 43093010,
        "stop": 43093010,
        "reference": "G",
        "alternate": "A",
        "representation": "VCF 1-based forward genomic"
      },
      "consequence": "missense_variant",
      "verified_gene_ids": [
        "ENSG00000012048"
      ],
      "transcript_count": 50,
      "source_id": "723e2a2d7d6c33c5967ae15630eaa8774cc739aa90372dd700d759360068f4be"
    }
  ]
}

Research findings

computational_result

Variant-level classification and conflict counts

Unique Variation IDs, germline VCV classification; explicit denominator for each ratio

{
  "classification_distribution": {
    "Benign": 8,
    "Benign/Likely benign": 3,
    "Conflicting classifications of pathogenicity": 12,
    "Likely benign": 2,
    "Pathogenic": 50,
    "Pathogenic/Likely pathogenic": 4,
    "Uncertain significance": 1
  },
  "official_conflicts": {
    "numerator": 12,
    "denominator": 80,
    "percent": 15.0
  },
  "same_condition_differences": {
    "numerator": 28,
    "denominator": 75,
    "percent": 37.333
  }
}

Deterministic lowest-ID sample, not random and not a population prevalence estimate.

computational_result

Documented classification differences

Current germline SCVs, exact NCBI MedGen condition-set match, independent organization IDs; P/LP and B/LB grouped separately from VUS

{
  "example_accessions": [
    "VCV000037388.28",
    "VCV000037398.31",
    "VCV000037399.26",
    "VCV000037402.33",
    "VCV000037405.20",
    "VCV000037715.26",
    "VCV000037717.29",
    "VCV000037718.27"
  ],
  "examples_found": 8
}

Current submission-level differences are not necessarily ClinVar aggregate conflicts; dates, review tiers and noncontributing submissions remain explicit.

computational_result

Review status and documentary completeness

Count official review labels and available SCV metadata, without invented reliability score

{
  "review_distribution": {
    "criteria provided, conflicting classifications": 12,
    "criteria provided, multiple submitters, no conflicts": 11,
    "criteria provided, single submitter": 3,
    "no assertion criteria provided": 2,
    "reviewed by expert panel": 52
  },
  "criteria": {
    "numerator": 1287,
    "denominator": 1770,
    "percent": 72.712
  },
  "dates": {
    "numerator": 1606,
    "denominator": 1770,
    "percent": 90.734
  },
  "citations": {
    "numerator": 1112,
    "denominator": 1770,
    "percent": 62.825
  }
}

Declared criteria/review tier do not establish correctness; missing metadata is not evidence of invalidity.

Excluded/invalid records and acquisition errors

{
  "exclusions": {
    "selected_variants": 80,
    "imported_variants": 80,
    "excluded_variants": 0,
    "reasons": {},
    "not_selected_query_ids": {
      "BRCA1": 14092,
      "BRCA2": 22006
    }
  },
  "errors": []
}

Scientific limits

Research only: no diagnosis, treatment or individual genetic analysis.
Sample is deterministic by lowest Variation ID within the official single-gene query; no representativeness claim.
VCV, RCV and SCV denominators are distinct. Germline classifications only.
Same-condition comparison requires identical NCBI-mapped MedGen condition sets; unresolved mappings are not forced.
P/LP and B/LB likelihood-only differences are separated from cross-band differences.
Contributing and noncontributing SCVs are reported separately; dates do not prove causes of disagreement.
VEP molecular consequence is independent of clinical classification; only exact GRCh38 SNVs qualified.
No artificial confidence/pathogenicity score, causal conclusion, clinical validation or model-weight learning.

Sources and reproducibility manifest

Each SHA256 refers to a complete cached API response, not the whole ClinVar database. Prefix probes of large TSV files are recorded separately and are not full-file checksums. API record versions are preserved; a common release timestamp is not assumed.

Official source URL	Acquisition UTC	Release/date metadata	Full response SHA256	Record counts
EMBL-EBI Ensembl	2026-11-06T00:45:14.296569+00:00	API response; see accession versions	`bb0e8b8cee31753642ee6905e1c5cd182d1c8358c5d14370c7374d18ffd72ef7`	{'examined': 1, 'matched': 1, 'invalid': 0}
NCBI ClinVar	2026-11-06T00:42:48.777789+00:00	API response; see accession versions	`8aefb0ad25a066e56a181c4166d5dc053e8d3d851abf104596e104205b871e03`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 5, 'current_germline_scv_records': 12, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:42:00.796620+00:00	API response; see accession versions	`acee4ba0f2e4f37fc9e26ce11ea29851df1126dc3a4577a5fb194be039f540e9`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 10, 'current_germline_scv_records': 26, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:42:34.124783+00:00	API response; see accession versions	`c63bf826107631756dd07cc76ea71c4183fec2a2626ae9676ab89b0af8f2e8f8`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 17, 'current_germline_scv_records': 101, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:43:19.755122+00:00	API response; see accession versions	`233d8fe5e13cdec62686306b842876438cb49654a57b30f4b2aeb5bf73774218`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 1, 'current_germline_scv_records': 3, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:50:03.164794+00:00	API response; see accession versions	`545804f4af50a1d9ef8392f723ab8cb03d201a4e3bb02d8be1390c9f97a4c055`	{'rcv_records': 1, 'matched_versioned_rcv': 1}
NCBI ClinVar	2026-11-06T00:42:04.991901+00:00	API response; see accession versions	`f14ff968d05fee9e6a9cdb858b655a35b98aab00deb54118e6c5ba134c3b427f`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 14, 'current_germline_scv_records': 76, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 1, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:43:21.819371+00:00	API response; see accession versions	`6afd202d4b05f4e0e1a16e81296cee439374dba4a19c7a7d8fb8b78c1ce85e51`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 8, 'current_germline_scv_records': 19, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:43:03.162142+00:00	API response; see accession versions	`738a08a741c1011d804edcb022fa3a0fc30a817bbbeee59ba81d693b31edf959`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 7, 'current_germline_scv_records': 12, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:43:11.816652+00:00	API response; see accession versions	`f2487d977f8666a0708a6ace9802c69b5354e84466167c92a8937fc2a2ef8195`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 6, 'current_germline_scv_records': 11, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:42:50.023361+00:00	API response; see accession versions	`9002964d42648aa9cbd82b783b1a583be37e84ce4747b79795c820043487756b`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 6, 'current_germline_scv_records': 11, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:42:59.555067+00:00	API response; see accession versions	`31ff675c326def7ee363368c1222ad43165fa136e2818c514d770ed83aa92add`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 1, 'current_germline_scv_records': 2, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:41:54.454682+00:00	API response; see accession versions	`5bb5bfd14d2b363c3d6a7efd713082495507987ce45627c2826d6fb34a90e69e`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 2, 'current_germline_scv_records': 2, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:42:26.927027+00:00	API response; see accession versions	`0c4a55d9118e41c7eda54cc5455479a88608b5297122553f32436dbf51fa6bb3`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 4, 'current_germline_scv_records': 20, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:41:35.681151+00:00	API response; see accession versions	`f599c7303c0f39437ec6f323cbc0b5460f08eb72038f25fbc4ecbbd807f0986c`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 10, 'current_germline_scv_records': 37, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:42:51.341846+00:00	API response; see accession versions	`accac92c0fd5e020a9eab6559a7ecf4d082dbdcf29fc903654e88db242033ac5`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 8, 'current_germline_scv_records': 16, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:42:44.747985+00:00	API response; see accession versions	`0a9db81e52253458b671ea454d4b55af2ffa0e1cc03042de66250da6692ab898`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 8, 'current_germline_scv_records': 28, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 1, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:42:06.608426+00:00	API response; see accession versions	`16d3b2ec0f7d3116cada146d4087f2c0787986e6d14af2cc81f1b702c70b317d`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 18, 'current_germline_scv_records': 97, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:42:54.856845+00:00	API response; see accession versions	`d3038e531b340f21d21d1eb91d4e7e08c4ad4177ef0cc4c099ac1565d8c48dfc`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 6, 'current_germline_scv_records': 20, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 1, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:42:53.802553+00:00	API response; see accession versions	`3543ac8db2d62e156f196376d315337f7e43a8ae261abe136ec0b2ad3e05214e`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 4, 'current_germline_scv_records': 13, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:41:48.628391+00:00	API response; see accession versions	`892d1c780aa55e4350ae47c0463a8267d8f6e98678f571e94938ccd83747862d`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 17, 'current_germline_scv_records': 72, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:42:02.378981+00:00	API response; see accession versions	`b0253aa166283bf21cbaf152d319a8dda0fee584ff7af6ea237f52c43e0147f5`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 11, 'current_germline_scv_records': 28, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:41:31.217622+00:00	API response; see accession versions	`5584d450db5dd0c144dd8781d4cefbfcecb65cafad95c46fca8471c780763b92`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 13, 'current_germline_scv_records': 60, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
EMBL-EBI Ensembl	2026-11-06T00:43:31.526438+00:00	API response; see accession versions	`572897a47dfaeb7ff837793bca0259cfef2eab49243e6d00a7c2a45e6d5d5127`	{'examined': 1, 'matched': 1, 'invalid': 0}
NCBI ClinVar	2026-11-06T00:42:38.366552+00:00	API response; see accession versions	`ab611eb20b716ed3e39e75558714f016dddc80604c4183f0c349fd3833e8c845`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 7, 'current_germline_scv_records': 22, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:50:07.917698+00:00	API response; see accession versions	`f78039662d54e368b9ac7898810681e018b85d929dad505f46b4982277eb2fda`	{'rcv_records': 1, 'matched_versioned_rcv': 1}
NCBI ClinVar	2026-11-06T00:43:20.279064+00:00	API response; see accession versions	`37900c5a5804bdecef84d1d03303a3af1732c1874d212b0a75e80e9fa79ac9c4`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 3, 'current_germline_scv_records': 4, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:43:04.120023+00:00	API response; see accession versions	`36194d5f4d11304c1ba0e938155a77c2cef98e8820844e0084d113b1c53f1337`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 4, 'current_germline_scv_records': 5, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 1, 'duplicate_scv': 0}}
EMBL-EBI Ensembl	2026-11-06T00:43:23.976697+00:00	API response; see accession versions	`bbfaf5b2a3dc1cd77f35e10b9e1659848e29cf19e4a76735e10803bccf1defb7`	{'gene_records': 1}
NCBI ClinVar	2026-11-06T00:42:01.487882+00:00	API response; see accession versions	`f1ad5fda2fdc0298a3761991a4fece5103e9248f0fb41487f6583cb27fa88943`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 6, 'current_germline_scv_records': 11, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:43:18.690658+00:00	API response; see accession versions	`b262dcc54475e1de1e187048d379a6873ff110253559a8d0224d30904c7bb0ef`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 4, 'current_germline_scv_records': 6, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:43:17.949547+00:00	API response; see accession versions	`6b883254facfe591d99e0e2c8eb4d32b66d1eaa2cb62cc1d3e1cea3ab51b3e89`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 7, 'current_germline_scv_records': 17, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:43:16.442564+00:00	API response; see accession versions	`94da40ac0d46385493afffd0e1534787b33d1217a327db6d31eaf764b85a97dd`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 6, 'current_germline_scv_records': 9, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:42:42.136511+00:00	API response; see accession versions	`bc39dc8dac37b24fe0a139f4a4fff8254826287b282bbcecf3a61c02550d45c7`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 1, 'current_germline_scv_records': 1, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:41:27.101007+00:00	API response; see accession versions	`d2ab7a4fedc1992f53d902771f46033635820c423e1a9cc6a8ae8b49bf1fadf4`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 3, 'current_germline_scv_records': 3, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:43:05.139812+00:00	API response; see accession versions	`738eb70bdbb3d1c9d7ceb5e49f02700e5fd7fb5cd9626b90b1358c1fb1398545`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 4, 'current_germline_scv_records': 9, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:42:35.289498+00:00	API response; see accession versions	`b140503e23bc5121601d7883aa630ba6bd2797d379a0b2fecba1e234b29948c2`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 1, 'current_germline_scv_records': 3, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:42:36.905350+00:00	API response; see accession versions	`5dbcbe2fb0a72d45a95d2bbf9add33b0ed7c8a5632db1d1ace9244f1de3b8ab3`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 8, 'current_germline_scv_records': 43, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:43:09.991813+00:00	API response; see accession versions	`3b1d1416c4b8f780821af2b7c95f0d4fcb61fde2b79c26264df4aa87633db3f3`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 6, 'current_germline_scv_records': 11, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:42:11.377187+00:00	API response; see accession versions	`59fa46bd1b0267e52337a0fc840f7d04b09d135fc702cd67a47de1a916b84343`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 6, 'current_germline_scv_records': 18, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:50:03.959953+00:00	API response; see accession versions	`01456287798362600f7d97933beb45ee8501bf07d16809f7dcbc860a914bdf8f`	{'rcv_records': 1, 'matched_versioned_rcv': 1}
EMBL-EBI Ensembl	2026-11-06T00:49:40.083365+00:00	API response; see accession versions	`a84369a08af1d703899b2bef52b0bc5a81c9deaf145a76ea99c5bde2e3279a4a`	{'examined': 1, 'matched': 1, 'invalid': 0}
EMBL-EBI Ensembl	2026-11-06T00:48:35.025658+00:00	API response; see accession versions	`b53ec05d978aa0c70d957258b51a527d0b3b42ad706ff864b0e0dc851466cc3c`	{'examined': 1, 'matched': 1, 'invalid': 0}
EMBL-EBI Ensembl	2026-11-06T00:43:59.622594+00:00	API response; see accession versions	`0bce032ec5075ab54d064952071e9f7b7b35ac215cb92840c6094da730feff1d`	{'examined': 1, 'matched': 1, 'invalid': 0}
NCBI ClinVar	2026-11-06T00:43:20.880236+00:00	API response; see accession versions	`733d7bc08cb168cddfdea18c31da407de12020bded2367b580c342e4586a3766`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 6, 'current_germline_scv_records': 14, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:41:55.337123+00:00	API response; see accession versions	`b7f58767d6f2b1d88fe930fd60b5e10a697d65d3140acb203659cd314c689406`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 6, 'current_germline_scv_records': 23, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
NCBI ClinVar	2026-11-06T00:41:51.007623+00:00	API response; see accession versions	`bb2532052b876e65dcbedb749249d624ddc7b18cc65362732df59fceb815fb18`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 17, 'current_germline_scv_records': 89, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
EMBL-EBI Ensembl	2026-11-06T00:43:40.225752+00:00	API response; see accession versions	`79885800e742dbcd45d473bd7adb52a154ef2025541f04b46ff99208f1a0ca03`	{'examined': 1, 'matched': 1, 'invalid': 0}
NCBI ClinVar	2026-11-06T00:41:52.031493+00:00	API response; see accession versions	`a29a7bce7d90a2ebe8545fca75429ea36aee9237ad8c51eeea4b9e82f889787a`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 9, 'current_germline_scv_records': 36, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
EMBL-EBI Ensembl	2026-11-06T00:47:20.666863+00:00	API response; see accession versions	`6e91a4f72a549b23290cedd5b7034ae0ab8ee1f4605ce8923760b1bcabdff872`	{'examined': 1, 'matched': 1, 'invalid': 0}
NCBI ClinVar	2026-11-06T00:43:11.172922+00:00	API response; see accession versions	`e03f956fc78c789e8f19d4c27a8bd1b1589a406e401d606a1789a030bacd9285`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 2, 'current_germline_scv_records': 2, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
EMBL-EBI Ensembl	2026-11-06T00:50:02.545387+00:00	API response; see accession versions	`00a36e98caf29be9a2c78873a691d6520fbee3d009f68e3a2e488d1f6f3dc43b`	{'examined': 1, 'matched': 1, 'invalid': 0}
NCBI ClinVar	2026-11-06T00:41:57.925818+00:00	API response; see accession versions	`db47fdde7f0137987d9e514506682e1aaac64b3ee987b446e215b88ee7672022`	{'examined': 1, 'imported': 1, 'excluded': 0, 'invalid': 0, 'rcv_records': 4, 'current_germline_scv_records': 5, 'excluded_scv_records': {'non_current_scv': 0, 'non_germline_scv': 0, 'duplicate_scv': 0}}
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